Stem Cells to Treat Vision Loss From Age-Related Macular Degeneration.

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

B Neumann, R Baror, C Zhao, M Segel, S Dietmann, KS Rawji, S Foerster, CR McClain, K Chalut, P van Wijngaarden, RJM Franklin

2019-10-03

Neumann et al. demonstrate that aging renders adult oligodendrocyte progenitor cells unresponsive to pro-differentiation factors, ..

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

AG De La Fuente, S Lange, ME Silva, GA Gonzalez, H Tempfer, P van Wijngaarden, C Zhao, L Di Canio, A Trost, L Bieler, P Zaunmair, P Rotheneichner, A O'Sullivan, S Couillard-Despres, O Errea, MA Mäe, J Andrae, L He, A Keller, LF Bátiz

2017-08-22

The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination,..

Pericytes promote the generation of oligodendrocytes during remyelination

A Guzman, S Lange, ME Silva, GA Gonzalez, H Tempfer, P van Wijngaarden, C Zhao, P Rotheneichner, A Trost, A O'Sullivan, S Couillard-Despres, L Bieler, O Errea, MA Mae, J Andrae, L He, A Keller, C Betsholtz, L Aigner, RJM Franklin

2017-06-01

Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

AG De La Fuente, O Errea, P Van Wijngaarden, GA Gonzalez, C Kerninon, AA Jarjour, HJ Lewis, CA Jones, B Nait-Oumesmar, C Zhao, JK Huang, C Ffrench-Constant, RJM Franklin

2015-01-01

The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understandi..